CrowPierce Technologies Patent Families
The patents and published applications are grouped into 9 families:
Families 1 and 2 relate to the growth of designated bacteria, that when induced results in the over-production of enzymes which delay the ripening (or extend the flowering) of climacteric fruits and/or vegetables. These patents then describe the various methods and manners in which these induced bacteria, and/or their isolated properties, can effect post-harvest ripening, resulting in extended shelf-life, while retaining all the attributes of full natural ripened fruit, etc.
Family 3 expands on the utility of specific bacteria when induced to delay the ripening climacteric fruit and vegetables, and to interact with those plant systems affected by the ethylene biosynthesis cascade system in plants. Also serves to protect non-climacteric, ethylene sensitive plant species when exposed to ethylene.
Family 4 relates to addressing aggressive ethylene biosynthesis seen during plant injury, such as including but not limited to excessive chilling or extended refrigeration. Normally, fruit exhibiting chill injury will rapidly decay, rendering these fruits unacceptable for consumption. The invention, when applied, results in these chill injured fruits having a period of consumer acceptance.
Family 5 relates to those plant specimens subjected to treatment according to the patent, exhibiting a significantly reduced and delayed onset of fungal/mold growth and decomposition of the plant specimen.
Family 6 relates to specific inhibition of molds and/or fungi.
Families 5, 6, and 7 in concert also pertain to inhibiting fungi which may not directly result in the decomposition of the plant specimen, can produce toxins that pose health issues for humans or animals that consume the infected plant specimens.
Fungi inhibited by the invention are not limited to situations involving a plant or plant part.
Family 8 relates to the production of an Asparaginase and/or an Asparaginase/Glutaminase, which inhibits and may kill those cancer cells that are incapable of producing asparagine. An example of such a cancer is Juvenile Acute Lymphoblastic Leukemia. The enzyme(s) produced by the invention are further characterized by the total lack of endotoxin. (All current asparaginase preparations contain endotoxin.). The Asparaginase of the invention shows a much higher affinity for the substrate and a much longer half-life than any current asparaginase product.
United States Patent Application Publication
Publication Number: US 2019/0275121 A1
Endotoxin Free Asparaginase
Sep 12, 2019. Pierce et al.
Inventors: George E. Pierce and Sidney A. Crow
United States Patent
Patent Number: US 7,531,343 B2
Introduction and Stabilization of Enzymatic Activity in Microorganisms
May 12, 2009. Pierce et al.
Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
United States Patent
Patent Number: US 7,531,344 B2
Induction and Stabilization of Enzymatic Activity in Microorganisms
May 12, 2009. Pierce et al.
Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
United States Patent
Patent Number: US 7,943,549 B2
Biological-Based Catalyst To Delay Plant Development Processes
May 17, 2011. Pierce et al.
Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago
United States Patent
Patent Number: US 8,323,942 B2
Method for Stabilizing Activity of Enzymes or Microorganisms Producing the Enzymes
Dec 4, 2022. Pierce et al.
Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
United States Patent
Patent Number: US 8,389,441 B2
Biological-Based Catalyst To Delay Plant Development Processes
March 5, 2013. Pierce et al.
Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
United States Patent
Patent Number: US 9,462,813
Biological-Based Catalyst To Delay Plant Development Processes
October 11, 2016. Pierce et al.
Inventors: George E. Pierce, Sangeeta Ganguly-Mink, Gene K. Drago
United States Patent
Patent Number: US 9,605,241 B2
Induction and Stabilization of Enzymatic Activity in Microorganisms
Mar. 28, 2017. Pierce et al.
Inventors: Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
United States Patent
Patent Number: US 9,993,005 B2
Preventing or Delaying Chill Injury Response in Plants
June 12, 2018. Pierce et al.
Inventors: George E. Pierce
United States Patent
Patent Number: US 10,004,237 B2
Inhibiting or Reducing Fungal Growth
June 26, 2018. Pierce et al.
Inventors: George E. Pierce and Sidney A. Crow
United States Patent
Patent Number: US 10,244,765 B2
Inhibiting or Reducing Fungal Growth
April 2, 2019. Pierce et al.
Inventors: George E. Pierce and Sidney Crow
United States Patent
Patent Number: US 10,300,093 B2
Inhibiting or Reducing Fungal Growth
May 28, 2019. Pierce et al.
Inventors: George E. Pierce and Sidney A. Crow
United States Patent
Patent Number: US 11,504,418 B2
Endotoxin Free Asparaginase
Nov 22, 2022. Pierce et al.
Inventors: George E. Pierce and Sidney A. Crow